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AI Primer
🔬 Research

evee

goodfire-aiby goodfire-ai15 days ago15

Look up pathogenicity, mechanistic interpretation, and disruption profiles for specific genetic variants via the EVEE API (Evo 2 genomic foundation model). Use when the user mentions a specific variant by gene name (BRCA1, TP53), rsID (rs1597537935), ClinVar variation ID (655979), HGVS notation (c.1234A>G, p.Arg412Gln), or genomic coordinate (chr17:43044295:A:G) — even if they don't mention "EVEE" or "ClinVar" by name. Trigger on questions about whether a variant is pathogenic, benign, or VUS; why it causes disease; how it compares to related variants; or what its predicted effect on protein/splicing/regulation is. Do NOT trigger on general gene-function questions, gene-expression analysis, CRISPR guide design, or evolutionary biology — this skill is for per-variant effect lookup only.

Install

npx skills add https://github.com/goodfire-ai/evee-mcp --skill evee
Show step-by-step
  1. 1

    Open your terminal

    • Mac: Press ⌘ Space, type "Terminal", press Enter
    • Windows: Press Win R, type "cmd", press Enter
  2. 2

    Paste the command above and press Enter

    Use the Copy command button, then paste in your terminal (Mac: ⌘V, Windows: Ctrl V).

  3. 3

    Restart Claude Code

    Close and reopen Claude Code, or start a new session, so it picks up the new skill.

Where it lives
~/.claude/skills/goodfire-ai--evee-mcp--claude--skills--evee/
├── SKILL.md
└── ... (skill resource files)
View on GitHub

Comments

X@GoodfireAI

"We've been blown away by the community's response to EVEE, our tool for SOTA genetic variant effect predictions. We're open-sourcing a tool to make it even..."

Always review skill code before installing. Third-party skills may contain scripts that run on your machine.

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